LCL-PEG3-N3

LCL-PEG3-N3 is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER (dec), degrading the estrogen receptor[1]. LCL-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[3033849-90-7]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lcl-peg3-n3.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(OCCOCCOCCN=[N+]=[N-])=CC=C1)C2=CSC([C@H]3N(C([C@H](C4CCCCC4)NC([C@H](C)NC)=O)=O)CCC3)=N2

Molecular Formula

C32H45N7O6S

Molecular Weight

655.81

References & Citations

[1]Miyako Naganuma, et al. Development of Chimeric Molecules That Degrade the Estrogen Receptor Using Decoy Oligonucleotide Ligands. ACS Med Chem Lett. 2022;13 (1) :134-139.