Spermine Prodrug-1
Spermine precursor-1 (Compound 1) is a redox-sensitive spermine precursor for the potential research of snyder robinson syndrome. Spermine precursor-1 inhibits wild-type (CMS-24949) and spermine synthase gene (SMS) mutant (CMS-26559, and CMS-6233) fibroblast cells with IC50s of 326.7, 198.5, and 244.1 μM, respectively[1].
Product Specifications
CAS Number
2576358-68-2
UNSPSC
12352211
Target
Drug Intermediate
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/spermine-prodrug-1.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C(C(C(C)(CC(NCCCNCCCCNCCCN)=O)C)=C(C1=O)C)=O)OC.[H]Cl.[H]Cl.[H]Cl
Molecular Formula
C24H45Cl3N4O5
Molecular Weight
576.00
References & Citations
[1]Mukund P Tantak, et al. Development of a Redox-Sensitive Spermine Prodrug for the Potential Treatment of Snyder Robinson Syndrome. J Med Chem. 2021 Nov 11;64 (21) :15593-15607.|[2]Mukund P Tantak, et al. Development of a Redox-Sensitive Spermine Prodrug for the Potential Treatment of Snyder Robinson Syndrome. J Med Chem. 2021 Nov 11;64 (21) :15593-15607.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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