LeuRS-IN-1 (hydrochloride)
LeuRS-IN-1 hydrochloride is a potent, orally active M. tuberculosis leucyl-tRNA synthetase (M.tb LeuRS) inhibitor. LeuRS-IN-1 hydrochloride has IC50 and Kd values of 0.06 μM, 0.075 μM for M.tb LeuRS, respectively[1]. LeuRS-IN-1 hydrochloride inhibits human cytoplasmic LeuRS (IC50=38.8 μM), and HepG2 protein synthesis (EC50=19.6 μM) [2].
Product Specifications
CAS Number
[1364683-67-9]
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/leurs-in-1-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CCOC1=C2C([C@H](OB2O)CN)=C(C=C1)Cl.Cl
Molecular Formula
C10H14BCl2NO3
Molecular Weight
277.94
References & Citations
Antimicrob Agents Chemother
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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