LeuRS-IN-1 (hydrochloride)

LeuRS-IN-1 hydrochloride is a potent, orally active M. tuberculosis leucyl-tRNA synthetase (M.tb LeuRS) inhibitor. LeuRS-IN-1 hydrochloride has IC50 and Kd values of 0.06 μM, 0.075 μM for M.tb LeuRS, respectively[1]. LeuRS-IN-1 hydrochloride inhibits human cytoplasmic LeuRS (IC50=38.8 μM), and HepG2 protein synthesis (EC50=19.6 μM) [2].

Product Specifications

CAS Number

[1364683-67-9]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/leurs-in-1-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

CCOC1=C2C([C@H](OB2O)CN)=C(C=C1)Cl.Cl

Molecular Formula

C10H14BCl2NO3

Molecular Weight

277.94

References & Citations

Antimicrob Agents Chemother

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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