Microtubule destabilizing agent-1
Product Specifications
UNSPSC Description
Microtubule destabilizing agent-1 (Compound 12b) acts as a microtubule destabilizing agent (MDA) based on hydroxamic acid, could serve as a potential MDA for further investigation. Microtubule destabilizing agent-1 shows favorable metabolism stability, high bioavailability, and potent antitumor activity[1].
Target Antigen
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/microtubule-destabilizing-agent-1.html
Solubility
10 mM in DMSO
Smiles
CN(C1=NC(C)=NC2=CC=CC=C12)C3=CC(OC(C(C)C)C(NO)=O)=C(OC)C=C3
Molecular Weight
410.47
References & Citations
[1]Linyu Yang, et al. Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity. J Med Chem. 2021 Oct 28;64(20):15379-15401.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-139981/Microtubule-destabilizing-agent-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139981/
Clinical Information
No Development Reported
CAS Number
2850370-28-2
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