BChE-IN-2

BChE-IN-2 (compound 22) is a potent inhibitor of BChE with a Ki of 0.099 μM. BChE-IN-2 is a pyrimidine and pyridine derivative. BChE-IN-2 has the potential for the research of Alzheimer’s disease (AD) [1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bche-in-2.html

Solubility

10 mM in DMSO

Smiles

C1(NCCCCCCCCCNCC2=CNC3=C2C=CC=C3)=NC=CC=N1

Molecular Formula

C22H31N5

Molecular Weight

365.52

References & Citations

[1]Bortolami M, et al. New Pyrimidine and Pyridine Derivatives as Multitarget Cholinesterase Inhibitors: Design, Synthesis, and In Vitro and In Cellulo Evaluation. ACS Chem Neurosci. 2021;12 (21) :4090-4112.