VPC-13789
VPC-13789 is a potent, selective, and orally bioavailable antiandrogen. VPC-13789 can be used for the research of castration-resistant prostate cancer (CRPC) therapeutics. VPC-13789 inhibits androgen receptor (AR) transcriptional activity in LNCaP cells (IC50=0.19 μM) [1].
Product Specifications
CAS Number
[2761146-51-2]
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/vpc-13789.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2C=CC(C3=CNC4=C3C=C(F)C(F)=C4F)=NC2=CC=C1)NC(C)C
Molecular Formula
C21H16F3N3O
Molecular Weight
383.37
References & Citations
[1]Eric Leblanc , et al. Development of 2- (5,6,7-Trifluoro-1 H-Indol-3-yl) -quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Prostate Cancer. J Med Chem. 2021 Oct 28;64 (20) :14968-14982.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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