(S) -CCG-1423
(S) -CCG-1423 is an inhibitor of Rho signaling that blocks the nuclear import of MRTF-A. (S) -CCG-1423 reduces the nuclear accumulation of MRTF-A and improves glucose uptake and tolerance in insulin-resistance mice in vivo. (S) -CCG-1423 exhibits higher inhibition activity than the SR- and the R-isomers of CCG-1423. (S) -CCG-1423 can be used for the research of cancer and diabetes[1].
Product Specifications
CAS Number
2319939-24-5
UNSPSC
12352005
Hazard Statement
H225-H350
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/s-ccg-1423.html
Solubility
10 mM in DMSO
Smiles
O=C(NO[C@@H](C)C(NC1=CC=C(Cl)C=C1)=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2
Molecular Formula
C18H13ClF6N2O3
Molecular Weight
454.75
Precautions
P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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