(S) -CCG-1423

(S) -CCG-1423 is an inhibitor of Rho signaling that blocks the nuclear import of MRTF-A. (S) -CCG-1423 reduces the nuclear accumulation of MRTF-A and improves glucose uptake and tolerance in insulin-resistance mice in vivo. (S) -CCG-1423 exhibits higher inhibition activity than the SR- and the R-isomers of CCG-1423 (HY-13991) . (S) -CCG-1423 can be used for the research of cancer and diabetes[1].

Product Specifications

CAS Number

[2319939-24-5]

UNSPSC

12352005

Hazard Statement

H225-H350

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/s-ccg-1423.html

Solubility

10 mM in DMSO

Smiles

O=C(NO[C@@H](C)C(NC1=CC=C(Cl)C=C1)=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2

Molecular Formula

C18H13ClF6N2O3

Molecular Weight

454.75

Precautions

P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P405-P501

References & Citations

[1]Watanabe B, et al. Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A. PLoS One. 2015 Aug 21;10 (8) :e0136242.