DHODH-IN-18
DHODH-IN-18 is a human DHODH inhibitor (IC50 = 0.2 nM) .
Product Specifications
CAS Number
2685799-97-5
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhodh-in-18.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=CC(F)=C1OC2=NN=CC3=C(F)C(N4N=C(CO)N(CC)C4=O)=NC(O[C@H](C(F)(F)F)C)=C32
Molecular Formula
C21H16ClF5N6O4
Molecular Weight
546.83
References & Citations
[1]Sabnis RW. Heterocyclic Compounds as Dihydroorotate Dehydrogenase Inhibitors for Treating Acute Myelogenous Leukemia (AML) . ACS Med Chem Lett. 2021 Oct 20;12 (11) :1641-1642.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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