Plasma kallikrein-IN-1
Plasma kallikrein-IN-1 is a PKK inhibitor with an IC50 value of 0.5 nM.
Product Specifications
CAS Number
[2691030-28-9]
UNSPSC
12352005
Target
Kallikrein
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/plasma-kallikrein-in-1.html
Solubility
10 mM in DMSO
Smiles
FC(F)C1=C(C=CC(N2CC3(CC3)C2)=N1)CN4C=NC(C(N[C@@H]5CCC6=C(C)NN=C65)=O)=C4
Molecular Formula
C23H25F2N7O
Molecular Weight
453.49
References & Citations
[1]Sabnis RW. Novel Heteroaromatic Carboxamides as Plasma Kallikrein Inhibitors for Treating Diabetic Complications, Ocular Diseases, and Edema-Associated Diseases. ACS Med Chem Lett. 2021 Oct 21;12 (11) :1637-1638.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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