Plasma kallikrein-IN-1

Plasma kallikrein-IN-1 is a PKK inhibitor with an IC50 value of 0.5 nM.

Product Specifications

CAS Number

[2691030-28-9]

UNSPSC

12352005

Target

Kallikrein

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/plasma-kallikrein-in-1.html

Solubility

10 mM in DMSO

Smiles

FC(F)C1=C(C=CC(N2CC3(CC3)C2)=N1)CN4C=NC(C(N[C@@H]5CCC6=C(C)NN=C65)=O)=C4

Molecular Formula

C23H25F2N7O

Molecular Weight

453.49

References & Citations

[1]Sabnis RW. Novel Heteroaromatic Carboxamides as Plasma Kallikrein Inhibitors for Treating Diabetic Complications, Ocular Diseases, and Edema-Associated Diseases. ACS Med Chem Lett. 2021 Oct 21;12 (11) :1637-1638.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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