EGFR-IN-18
EGFR-IN-18 potently inhibits enzymatic activity in L858R/T790M/C797S mutant EGFR (4.9 nM), with a significantly lower activity for wild-type EGFR (47 nM) .
Product Specifications
CAS Number
[2765573-34-8]
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-18.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC(C2=C(C3=CC(NC(C)=O)=NC=C3)NC(SC)=N2)=C1)C4=CC=CC=C4CN(CC5=C6C=CC=C5)C6=O
Molecular Formula
C33H28N6O3S
Molecular Weight
588.68
References & Citations
[1]Wittlinger F, et al. Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites. J Med Chem. 2021 Oct 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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