BTK inhibitor 19

BTK inhibitor 19 is a highly selective, covalent BTK inhibitor (IC50 = 2.7 nM) .

Product Specifications

CAS Number

[2557174-19-1]

UNSPSC

12352005

Target

Btk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/btk-inhibitor-19.html

Solubility

10 mM in DMSO

Smiles

NC(C1=C(C2=CC=C(C(NC3=NC=CC(C(F)(F)F)=C3)=O)C=C2)N=C([C@@H]4CCCCN4C(C=C)=O)N1N)=O

Molecular Formula

C25H24F3N7O3

Molecular Weight

527.50

References & Citations

[1]Ma C, et al. Discovery of 1-Amino-1H-imidazole-5-carboxamide Derivatives as Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitors. J Med Chem. 2021 Nov 11;64 (21) :16242-16270.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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