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HTrkA-IN-2

HTrkA-IN-2 is a selective hTrkA allosteric inhibitor with an IC50 value of 3.9 nM.

Product Specifications

CAS Number

2986533-14-4

UNSPSC

12352005

Target

Trk Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/htrka-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=C(C2=CC=CC=C2)N=C3N1C=CN=C3C)NCC4=C(OC(F)(F)F)C=CC(COC)=C4

Molecular Formula

C24H22F3N5O3

Molecular Weight

485.46

References & Citations

[1]Subramanian G, et al. In Pursuit of an Allosteric Human Tropomyosin Kinase A (hTrkA) Inhibitor for Chronic Pain. ACS Med Chem Lett. 2021 Oct 25;12 (11) :1847-1852.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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