Keap1-Nrf2-IN-3
Product Specifications
UNSPSC Description
Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein−protein interaction inhibitor, and with a Kd value of 2.5 nM for KEAP1 protein.
Target Antigen
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/keap1-nrf2-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C([C@H]2[C@H](C3=CN(C)N=N3)C2)N(C4=CC=CC(C5=CC=CC(C(N6[C@H](CCC)CCCC6)=O)=C5)=C4)N=C1)O
Molecular Weight
538.64
References & Citations
[1]Norton D, et al. Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction. J Med Chem. 2021 Nov 11;64(21):15949-15972.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-139862/Keap1-Nrf2-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139862/
Clinical Information
No Development Reported
CAS Number
2095066-47-8
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
IRBAMLIDH3BAP812200UL 200 µL
Rabbit Anti IDH3B Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Immunofluorescence) 200ul
Ask
View Details 
MBS2060765-01 0.1 mL
APC/CY7-Linked Monoclonal Antibody to Leucine Rich Alpha-2-Glycoprotein 1 (LRG1)
Ask
View Details 
MBS2060765-02 0.2 mL
APC/CY7-Linked Monoclonal Antibody to Leucine Rich Alpha-2-Glycoprotein 1 (LRG1)
Ask
View Details MBS2060765-03 0.5 mL
APC/CY7-Linked Monoclonal Antibody to Leucine Rich Alpha-2-Glycoprotein 1 (LRG1)
Ask
View Details