Keap1-Nrf2-IN-3
Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein−protein interaction inhibitor, and with a Kd value of 2.5 nM for KEAP1 protein.
Product Specifications
CAS Number
2095066-47-8
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/keap1-nrf2-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C([C@H]2[C@H](C3=CN(C)N=N3)C2)N(C4=CC=CC(C5=CC=CC(C(N6[C@H](CCC)CCCC6)=O)=C5)=C4)N=C1)O
Molecular Formula
C31H34N6O3
Molecular Weight
538.64
References & Citations
[1]Norton D, et al. Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction. J Med Chem. 2021 Nov 11;64 (21) :15949-15972.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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