PLAP-IN-1
PLAP-IN-1 is a potent (IC50 = 32 nM) and selective PLAP inhibitor, with no detectable inhibition of tissue non-specific alkaline phosphatase (TNAP) activity.
Product Specifications
CAS Number
2857113-78-9
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/plap-in-1.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(OC)C(Cl)=CC(C2=CC=CC(C[C@@H](NC(C3=NNC(C4=CC=C(C)O4)=C3)=O)C(O)=O)=C2)=C1
Molecular Formula
C25H21Cl2N3O5
Molecular Weight
514.36
References & Citations
[1]Bassi G, et al. Specific Inhibitor of Placental Alkaline Phosphatase Isolated from a DNA-Encoded Chemical Library Targets Tumor of the Female Reproductive Tract. J Med Chem. 2021 Nov 11;64 (21) :15799-15809.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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