GPS491
GPS491 (EC50 = 0.47 μM) suppresses expression of the HIV-1 structural protein Gag and alters HIV-1 RNA accumulation, decreasing the abundance of RNAs encoding the structural proteins while increasing levels of viral RNAs encoding the regulatory proteins.
Product Specifications
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gps491.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC(C=CC(C(F)(F)F)=C2)=C2S1)C3=CN=C(C(F)(F)F)S3
Molecular Formula
C13H5F6N3OS2
Molecular Weight
397.32
References & Citations
[1]Zamiri M, et al. 2-Trifluoromethylthiazole-5-carboxamides: Analogues of a Stilbene-Based Anti-HIV Agent that Impact HIV mRNA Processing. ACS Med Chem Lett. 2021 Oct 29;12 (11) :1818-1823.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-139850/GPS491-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139850/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
CAS Number
[2655502-29-5]
Available Sizes
Curated Selection
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