MK-4688
MK-4688 is an efficient inhibitor of the HDM2-p53 protein-protein interaction.
Product Specifications
CAS Number
[1616428-79-5]
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mk-4688.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](CC1)CC[C@H]1CN(C(N2CCO[C@H]3[C@H]2CCC3)=N4)C5=C4C=C(C(N6)=NOC6=O)N=C5C7=CC(Cl)=CN=C7
Molecular Formula
C28H32ClN7O3
Molecular Weight
550.05
References & Citations
[1]Reutershan MH, et al. Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction. J Med Chem. 2021 Nov 11;64 (21) :16213-16241.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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