Dyrk1A-IN-1
Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity (IC50 = 119 nM) and the aggregation of tau and α-syn oligomers.
Product Specifications
CAS Number
[2858696-72-5]
UNSPSC
12352005
Target
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dyrk1a-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC2=C(C=C(O)C=C2)S1)NC3=CC=C(C(NCCC4=CC=CC=C4)=O)C=C3
Molecular Formula
C23H20N4O3S
Molecular Weight
432.49
References & Citations
[1]Aboushady Y, et al. Discovery of Hydroxybenzothiazole Urea Compounds as Multitargeted Agents Suppressing Major Cytotoxic Mechanisms in Neurodegenerative Diseases. ACS Chem Neurosci. 2021 Nov 17;12 (22) :4302-4318.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1
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