Dyrk1A-IN-1
Product Specifications
UNSPSC Description
Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity (IC50 = 119 nM) and the aggregation of tau and α-syn oligomers.
Target Antigen
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dyrk1a-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC2=C(C=C(O)C=C2)S1)NC3=CC=C(C(NCCC4=CC=CC=C4)=O)C=C3
Molecular Weight
432.49
References & Citations
[1]Aboushady Y, et al. Discovery of Hydroxybenzothiazole Urea Compounds as Multitargeted Agents Suppressing Major Cytotoxic Mechanisms in Neurodegenerative Diseases. ACS Chem Neurosci. 2021 Nov 17;12(22):4302-4318.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-139830/Dyrk1A-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139830/
Clinical Information
No Development Reported
CAS Number
2858696-72-5
Curated Selection
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