PRMT5-IN-11
PRMT5-IN-11 is a promising structure-dependent inhibition of the protein methyltransferase PRMT5:MEP50 complex in the (sub) micromolar range.
Product Specifications
CAS Number
[2567564-33-2]
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/prmt5-in-11.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1[C@@]([C@H]2O)(CC1)O[C@](N3C4=NC=NC(N)=C4N=C3)([H])[C@@H]2O
Molecular Formula
C13H17N5O4
Molecular Weight
307.31
References & Citations
[1]Jouffroy L, et al. Regio- and Stereoselective Synthesis of C-4' Spirocyclobutyl Ribofuranose Scaffolds and Their Use as Biologically Active Nucleoside Analogues. Org Lett. 2021 Nov 19;23 (22) :8828-8833.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT5
Curated Selection
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