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VEGFR-2-IN-10

VEGFR-2-IN-10 exhibits increased antiangiogenic potency (IC50 = 0.7 μM) against VEGF-induced VEGFR2 phosphorylation without cytotoxic effects.

Product Specifications

CAS Number

2760792-40-1

UNSPSC

12352005

Target

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegfr-2-in-10.html

Solubility

10 mM in DMSO

Smiles

COC1=CC2=C(NC3=C2CN(C(CC4=NC=CC=C4)=O)CCC3)C=C1

Molecular Formula

C20H21N3O2

Molecular Weight

335.40

References & Citations

[1]Cho SM, et al. Development of Novel VEGFR2 Inhibitors Originating from Natural Product Analogues with Antiangiogenic Impact. J Med Chem. 2021 Nov 11;64 (21) :15858-15867.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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