DDR1-IN-1 dihydrochloride
DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM) [1].
Product Specifications
CAS Number
1780303-76-5
UNSPSC
12352005
Target
Discoidin Domain Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ddr1-in-1-dihydrochloride.html
Purity
95.21
Solubility
H2O : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=C(C=C(C=C1)NC(C2=CC=C(C(C(F)(F)F)=C2)CN3CCN(CC3)CC)=O)OC4=CC(C5)=C(C=C4)NC5=O.Cl.Cl
Molecular Formula
C30H33Cl2F3N4O3
Molecular Weight
625.51
References & Citations
[1]Kim HG, et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol. 2013 Oct 18;8 (10) :2145-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DDR1; DDR2
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