Donidalorsen (sodium)

Donidalorsen (sodium) is an antisense oligonucleotide designed to reduce the production of prekallikrein (PKK) . PKK plays an important role in the activation of inflammatory mediators associated with acute attacks of Hereditary angioedema (HAE) .

Product Specifications

CAS Number

[2304701-45-7]

Product Name Alternative

ISIS-721744; IONIS-PKK-LRX

UNSPSC

12352208

Target

Kallikrein

Type

Oligonucleotides

Related Pathways

Immunology/Inflammation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/donidalorsen-sodium.html

Purity

95.90

Solubility

10 mM in H2O

Smiles

[Donidalorsen(sodium)]

Molecular Formula

C296H415N83Na20O151P20S15

Molecular Weight

8672.6 (free acid)

References & Citations

[1]Fijen LM, Riedl MA, Bordone L, et al. Inhibition of Prekallikrein for Hereditary Angioedema. N Engl J Med. 2022;386 (11) :1026-1033. |[2]Valerieva A, Longhurst HJ. Treatment of hereditary angioedema-single or multiple pathways to the rescue. Front Allergy. 2022;3:952233.