Donidalorsen (sodium)
Donidalorsen (sodium) is an antisense oligonucleotide designed to reduce the production of prekallikrein (PKK) . PKK plays an important role in the activation of inflammatory mediators associated with acute attacks of Hereditary angioedema (HAE) .
Product Specifications
CAS Number
2304701-45-7
Product Name Alternative
ISIS-721744; IONIS-PKK-LRX
UNSPSC
12352208
Target
Kallikrein
Type
Oligonucleotides
Related Pathways
Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/donidalorsen-sodium.html
Purity
95.90
Solubility
10 mM in H2O
Smiles
[Donidalorsen(sodium)]
Molecular Formula
C296H415N83Na20O151P20S15
Molecular Weight
8672.6 (free acid)
References & Citations
[1]Fijen LM, Riedl MA, Bordone L, et al. Inhibition of Prekallikrein for Hereditary Angioedema. N Engl J Med. 2022;386 (11) :1026-1033. |[2]Valerieva A, Longhurst HJ. Treatment of hereditary angioedema-single or multiple pathways to the rescue. Front Allergy. 2022;3:952233.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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