Donidalorsen
Donidalorsen is an antisense oligonucleotide designed to reduce the production of prekallikrein (PKK) . PKK plays an important role in the activation of inflammatory mediators associated with acute attacks of Hereditary angioedema (HAE) .
Product Specifications
CAS Number
2304692-48-4
Product Name Alternative
ISIS-721744 (free acid) ; IONIS-PKK-LRX (free acid)
UNSPSC
12352208
Target
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/donidalorsen.html
Solubility
10 mM in H2O
Smiles
[Donidalorsen]
Molecular Formula
C296H435N83O151P20S15
Molecular Weight
8672.64
References & Citations
[1]Fijen LM, Riedl MA, Bordone L, et al. Inhibition of Prekallikrein for Hereditary Angioedema. N Engl J Med. 2022;386 (11) :1026-1033. |[2]Valerieva A, Longhurst HJ. Treatment of hereditary angioedema-single or multiple pathways to the rescue. Front Allergy. 2022;3:952233.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
Launched
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