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Cavrotolimod (sodium)

Cavrotolimod sodium is an immunostimulatory spherical nucleic acid (SNA) modified with type B CpG oligonucleotides designed to agonize TLR9 and elicit immune responses useful in oncology applications.

Product Specifications

Product Name Alternative

AST-008 (sodium)

UNSPSC

12352208

Target

Toll-like Receptor (TLR)

Type

Oligonucleotides

Related Pathways

Immunology/Inflammation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/cavrotolimod-sodium.html

Solubility

10 mM in H2O

Smiles

[Cavrotolimod(sodium)]

Molecular Formula

C300H399N71Na24O161P26S23

Molecular Weight

9142.88 (free acid)

References & Citations

[1]Daniel WL, Lorch U, Mix S, Bexon AS. A first-in-human phase 1 study of cavrotolimod, a TLR9 agonist spherical nucleic acid, in healthy participants: Evidence of immune activation. Front Immunol. 2022;13:1073777.|[2]Rubatto M, Sciamarrelli N, Borriello S, et al. Classic and new strategies for the treatment of advanced melanoma and non-melanoma skin cancer. Front Med (Lausanne) . 2023;9:959289.

Shipping Conditions

Room temperature

Scientific Category

Oligonucleotides

Clinical Information

Phase 2

Frequently Asked Questions

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