β-Secretase Inhibitor III
β-Secretase Inhibitor III is an extremely selective BACE1 inhibitor (Ki = 0.13 nM) .
Product Specifications
CAS Number
2760674-85-7
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/β-secretase-inhibitor-iii.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=C(OCCO2)C=N1)NC3=CC=C(F)C([C@@]4(C)N=C(N)S[C@H](C)[C@@H]4F)=C3
Molecular Formula
C20H20F2N4O3S
Molecular Weight
434.46
References & Citations
[1]Ueno T, et al. Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions. J Med Chem. 2021 Oct 14;64 (19) :14165-14174.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1
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