IMD-biphenylB
IMD-biphenylB is a potent imidazoquinolinone-NF-κB immunomodulator dimer that inhibits tumor proliferation while induces low systemic inflammation and reduces adjuvant toxicity.
Product Specifications
CAS Number
2928463-41-4
UNSPSC
12352005
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/imd-biphenylb.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(C=CC=C2)=C2C3=C1N=C(CCCC)N3CC4=CC=C(CNC(C5=C(O)C=C(C6=CC(O)=CC=C6)C=C5)=O)C=C4
Molecular Formula
C35H33N5O3
Molecular Weight
571.67
References & Citations
[1]Kimani FW, et al. Improving the Adjuvanticity of Small Molecule Immune Potentiators Using Covalently Linked NF-κB Modulators. ACS Med Chem Lett. 2021 Aug 26;12 (9) :1441-1448.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NF-κB
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