NI-Pano
NI-Pano (CH-03) is a novel hypoxia-activated KDAC inhibitor. NI-Pano (CH-03) is reduced in an O2-dependent manner to release panobinostat.
Product Specifications
CAS Number
[2733559-66-3]
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ni-pano.html
Solubility
10 mM in DMSO
Smiles
CC(N1)=C(CCNCC2=CC=C(/C=C/C(NOCC3=CN=C([N+]([O-])=O)N3C)=O)C=C2)C4=C1C=CC=C4
Molecular Formula
C26H28N6O4
Molecular Weight
488.54
References & Citations
[1]Skwarska A, et al. Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor. Cell Chem Biol. 2021 Sep 16;28 (9) :1258-1270.e13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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