GT-1

GT-1 (LCB10-0200), a siderophore-linked cephalosporin, is effective against clinical isolates of P. aeruginosa, Klebsiella oxytoca, Proteus spp., Serratia marcescens, and Enterobacter aerogenes.

Product Specifications

CAS Number

[1401527-90-9]

Product Name Alternative

LCB10-0200

UNSPSC

12352005

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/gt-1.html

Solubility

10 mM in DMSO

Smiles

OC1=CN(O)C(C(NCCNC2=C[N+](CC3=C(C([O-])=O)N4[C@@H]([C@H](NC(/C(C5=C(Cl)SC(N)=N5)=N\OC(C)(C)C(O)=O)=O)C4=O)SC3)=CN=C2N)=O)=CC1=O

Molecular Formula

C29H30ClN11O11S2

Molecular Weight

808.20

References & Citations

[1]Halasohoris SA, et al. In vitro and in vivo activity of GT-1, a novel siderophore cephalosporin, and GT-055, a broad-spectrum β-lactamase inhibitor, against biothreat and ESKAPE pathogens. J Antibiot (Tokyo) . 2021 Dec;74 (12) :884-892.