5-HT7R antagonist 1 (free base)
5-HT7R antagonist 1 (free base) is a G protein-biased antagonist against 5-HT7R (Ki = 6.5 nM) .
Product Specifications
CAS Number
2337008-64-5
UNSPSC
12352005
Target
G protein-coupled Bile Acid Receptor 1
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-ht7r-antagonist-1-free-base.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(C2=NNC=C2N3CCNCCC3)=CC=C1
Molecular Formula
C14H17ClN4
Molecular Weight
276.76
References & Citations
[1]Kwag R, et al. Discovery of G Protein-Biased Antagonists against 5-HT7R. J Med Chem. 2021 Sep 23;64 (18) :13766-13779.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT7 Receptor
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