Ten01

Ten01 has 5.0 nM activity against JAK1 kinase.

Product Specifications

UNSPSC

12352005

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ten01.html

Solubility

10 mM in DMSO

Smiles

FC(F)(F)C1=CN=C(NC=C2)C2=C1C[C@H]3CN(C(NCC(F)(F)F)=O)C[C@@H]3CC

Molecular Formula

C18H20F6N4O

Molecular Weight

422.37

References & Citations

[1]Yu Y, et al. A Novel Scalarized Scaffold Hopping Algorithm with Graph-Based Variational Autoencoder for Discovery of JAK1 Inhibitors. ACS Omega. 2021 Aug 24;6 (35) :22945-22954.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

JAK1

Curated Selection

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