Ascochlorin A
Product Specifications
CAS Number
[2550720-02-8]
UNSPSC Description
Ascochlorin A is a novel and potent hDHODH inhibitor (KD = 3.29 μM) for research of triple-negative breast cancer.
Target Antigen
Dihydroorotate Dehydrogenase; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ascochlorin-a.html
Solubility
10 mM in DMSO
Smiles
OC(C(C=O)=C(C(Cl)=C1O)C)=C1C/C=C(C)/CC[C@H]2C(C)([C@H](CCC2=C)O)C
Molecular Weight
406.94
References & Citations
[1]Luo X, et al. Exploring Marine-Derived Ascochlorins as Novel Human Dihydroorotate Dehydrogenase Inhibitors for Treatment of Triple-Negative Breast Cancer. J Med Chem. 2021 Sep 23;64(18):13918-13932.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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