VCP/p97 inhibitor-1
VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS) [1][2].
Product Specifications
CAS Number
2630950-38-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
P97
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vcp-p97-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
O=S(NC1=CC=CC2=C1C=C(C)N2C3=NC(CCC4)=C4C(NCC5=CC(B(O)O)=CC=C5)=N3)(C)=O
Molecular Formula
C24H26BN5O4S
Molecular Weight
491.37
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Zhang Y, et al. Discovery of novel pyrimidine molecules containing boronic acid as VCP/p97 Inhibitors. Bioorg Med Chem. 2021;38:116114.|[2]van den Boom J, et al. VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. Mol Cell. 2018;69 (2) :182-194.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC680149-500 1x 500 µL
CD106 / VCAM1 (1.4C3), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC471003-500 1x 500 µL
Mucin 5AC (MUC5AC) (58M1), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680485-100 1x 100 µL
ODC-1 (Ornithine Decarboxylase-1) (ODC1/485), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC471810-100 1x 100 µL
Spectrin Alpha 1 (Erythrocyte Marker) (SPTA1/1810), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC402714-100 1x 100 µL
Carboxypeptidase A1 / CPA1 (Pancreatic Cancer Marker) (CPA1/2714), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details