Ulevostinag
Product Specifications
UNSPSC Description
Ulevostinag (MK-1454) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (MK-1454) acts in the intra-tumoral route by targeting the stimulator of interferon genes (STING) protein. Ulevostinag (MK-1454) can be used for immuno-tumor cancer disease research[1].
Target Antigen
STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ulevostinag.html
Purity
99.14
Solubility
10 mM in DMSO
Smiles
F[C@H]1[C@](O[P@](S)(OC[C@](O[C@](N2C3=NC=NC(N)=C3N=C2)([H])[C@H]4F)([H])[C@@]4([H])O5)=O)([H])[C@@](N6C(NC(N)=NC7=O)=C7N=C6)([H])O[C@]1([H])CO[P@]5(S)=O
Molecular Weight
710.52
References & Citations
[1]Zawit M, et al. Current status of intralesional agents in treatment of malignant melanoma. Ann Transl Med. 2021 Jun;9(12):1038.|[2]Gogoi H, et al. The Age of Cyclic Dinucleotide Vaccine Adjuvants. Vaccines (Basel). 2020 Aug 13;8(3):453.|[3]Chang W, et al. Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer. J Med Chem. 2022 Apr 14;65(7):5675-5689.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-139586/Ulevostinag-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139586/Ulevostinag-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
2082743-96-0
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