Ulevostinag

Ulevostinag (MK-1454) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING) . Ulevostinag (MK-1454) acts in the intra-tumoral route by targeting the stimulator of interferon genes (STING) protein. Ulevostinag (MK-1454) can be used for immuno-tumor cancer disease research[1].

Product Specifications

CAS Number

[2082743-96-0]

Product Name Alternative

MK-1454

UNSPSC

12352005

Target

STING

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ulevostinag.html

Purity

99.14

Solubility

10 mM in DMSO

Smiles

F[C@H]1[C@](O[P@](S)(OC[C@](O[C@](N2C3=NC=NC(N)=C3N=C2)([H])[C@H]4F)([H])[C@@]4([H])O5)=O)([H])[C@@](N6C(NC(N)=NC7=O)=C7N=C6)([H])O[C@]1([H])CO[P@]5(S)=O

Molecular Formula

C20H22F2N10O9P2S2

Molecular Weight

710.52

References & Citations

[1]Zawit M, et al. Current status of intralesional agents in treatment of malignant melanoma. Ann Transl Med. 2021 Jun;9 (12) :1038.|[2]Gogoi H, et al. The Age of Cyclic Dinucleotide Vaccine Adjuvants. Vaccines (Basel) . 2020 Aug 13;8 (3) :453.|[3]Chang W, et al. Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer. J Med Chem. 2022 Apr 14;65 (7) :5675-5689.