BMS-986318
Product Specifications
UNSPSC Description
BMS-986318 is a potent nonbile acid FXR agonist with EC50s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays, respectively. BMS-986318 has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.BMS-986318 can be used for the research of nonalcoholic steatohepatitis[1].
Target Antigen
FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bms-986318.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(C(F)(F)F)=C2C=C(N3CCC4(CC3)C=C(C4)C5=C(C6CC6)ON=C5C7=C(Cl)C=NC=C7Cl)C=CC2=N1)O
Molecular Weight
615.43
References & Citations
[1]Joseph Carpenter, et al. Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis. ACS Med Chem Lett. 2021 Aug 5;12(9):1413-1420.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-139562/BMS-986318-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139562/
Clinical Information
Phase 1
CAS Number
2314378-09-9
Curated Selection
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