Thalidomide-4-C3-NH2 (hydrochloride)
Thalidomide-4-C3-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-C3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].
Product Specifications
CAS Number
[2357110-84-8]
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-4-c3-nh2-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(C(CC1)N2C(C3=CC=C(CCCN)C=C3C2=O)=O)=O.Cl
Molecular Formula
C16H18ClN3O4
Molecular Weight
351.78
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501
References & Citations
[1]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-994.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
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