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Pomalidomide-5-O-CH3

Pomalidomide-5-O-CH3 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-O-CH3 can be connected to the ligand for protein by a linker to form PROTAC[1].

Product Specifications

CAS Number

1547163-02-9

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pomalidomide-5-o-ch3.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=CC=C(C(N)=C2C(N1C3C(NC(CC3)=O)=O)=O)OC

Molecular Formula

C14H13N3O5

Molecular Weight

303.27

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Andrew J. Phillips, et al. Bromodomain targeting degronimers for target protein degradation. WO2017197056A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

Frequently Asked Questions

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