PF-03622905
PF-03622905 is a potent and ATP-competitive PKC inhibitor with IC50s of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM, and 74.1 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCθ, respectively. PF-03622905 shows high specificity for PKC over other protein kinases[1].
Product Specifications
CAS Number
1072100-15-2
UNSPSC
12352005
Target
PKC; SHP2
Type
Reference compound
Related Pathways
Epigenetics; Protein Tyrosine Kinase/RTK; TGF-beta/Smad
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pf-03622905.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC=N1)NC2=NNC3=C2CN(C(N4C[C@H](N(C[C@@H]4C)CCC)CCO)=O)C3(C)C
Molecular Formula
C24H35N7O3
Molecular Weight
469.58
References & Citations
[1]Stephan Grant, et al. Discovery of a novel class of targeted kinase inhibitors that blocks protein kinase C signaling and ameliorates retinal vascular leakage in a diabetic rat model. Eur J Pharmacol. 2010 Feb 10;627 (1-3) :16-25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKCα; PKCβ; PKCγ; PKCθ
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