2-Deoxy-D-glucose 6-phosphate

2-Deoxy-D-glucose 6-phosphate , a derivative of 2-Deoxy-D-glucose (HY-13966), is produced in mammalian cells by the action of hexokinase on 2-DG. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

Product Specifications

CAS Number

[3573-50-0]

UNSPSC

12352211

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-deoxy-d-glucose-6-phosphate.html

Solubility

10 mM in DMSO

Smiles

O=P(O)(O)OC[C@@H](O)[C@@H](O)[C@H](O)CC=O

Molecular Formula

C6H13O8P

Molecular Weight

244.14

References & Citations

[1]Zhu Z, et al. 2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro. Cancer Res. 2005 Aug 1;65 (15) :7023-30.|[2]B Pajak, et al. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents. Int J Mol Sci. 2019 Dec 29;21 (1) :234.