Fmoc-Phe-Lys (Boc) -PAB
Fmoc-Phe-Lys (Boc) -PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[206133-42-8]
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fmoc-phe-lys-boc-pab.html
Solubility
10 mM in DMSO
Smiles
OCC(C=C1)=CC=C1NC([C@H](CCCCNC(OC(C)(C)C)=O)NC([C@H](CC2=CC=CC=C2)NC(OCC3C4=CC=CC=C4C5=CC=CC=C53)=O)=O)=O
Molecular Formula
C42H48N4O7
Molecular Weight
720.85
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Raymond Firestone, et al. Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells. WO1998013059A1.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Protease Cleavable Linker
Available Sizes
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