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CDK12-IN-4

CDK12-IN-4, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 0.641 μM at high ATP (2 mM) . CDK12-IN-4 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1) [1].

Product Specifications

CAS Number

2651196-69-7

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk12-in-4.html

Solubility

10 mM in DMSO

Smiles

FC1=C(F)C2=C(N=C(CNC3=NC(N4CCOCC4)=NC5=C(C6CC6)C=NN35)N2)C=C1

Molecular Formula

C20H20F2N8O

Molecular Weight

426.42

References & Citations

[1]Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK12; CDK2; CDK9

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