PROTAC IRAK4 degrader-4
PROTAC IRAK4 degrader-4 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-127[1].
Product Specifications
CAS Number
[2360528-45-4]
UNSPSC
12352005
Target
IRAK; PROTACs
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-irak4-degrader-4.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NN(C2=CC=C(C(NCCOCCOCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)C=C2)C=C1NC(C6=COC(C7=CC(NCC(F)(F)F)=NC=C7)=N6)=O)N
Molecular Formula
C41H38F3N11O10
Molecular Weight
901.80
References & Citations
[1]US20190192668A1
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4
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