PROTAC IRAK4 degrader-4

PROTAC IRAK4 degrader-4 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-127[1].

Product Specifications

CAS Number

[2360528-45-4]

UNSPSC

12352005

Target

IRAK; PROTACs

Type

Reference compound

Related Pathways

Immunology/Inflammation; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-irak4-degrader-4.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NN(C2=CC=C(C(NCCOCCOCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)C=C2)C=C1NC(C6=COC(C7=CC(NCC(F)(F)F)=NC=C7)=N6)=O)N

Molecular Formula

C41H38F3N11O10

Molecular Weight

901.80

References & Citations

[1]US20190192668A1

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IRAK4

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