FNC-TP (trisodium)
Product Specifications
UNSPSC Description
FNC-TP trisodium is the intracellular active form of FNC. FNC is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV[1]. FNC-TP (trisodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Target Antigen
HBV; HCV; HIV; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/fnc-tp-trisodium.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(O[Na])OP(OP(OC[C@]1(O[C@](N2C(N=C(C=C2)N)=O)([H])[C@H]([C@@H]1O)F)N=[N+]=[N-])(O[Na])=O)(O[Na])=O
Molecular Weight
592.11
References & Citations
[1]Sun L, et, al. Mechanistic Insight into Antiretroviral Potency of 2'-Deoxy-2'-β-fluoro-4'-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention. J Med Chem. 2020 Aug 13;63(15):8554-8566.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-139262A/FNC-TP-trisodium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139262A/
Clinical Information
No Development Reported
Curated Selection
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