XVA143
XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo[1].
Product Specifications
CAS Number
264275-77-6
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/xva143.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)[C@H](CNC(C1=CC(O)=CC(O)=C1)=O)NC(C2=C(Cl)C=C(C(NCC3=CC=CC(O)=C3)=O)C=C2Cl)=O
Molecular Formula
C25H21Cl2N3O8
Molecular Weight
562.36
References & Citations
[1]Azucena Salas, et al. Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction. Immunity. 2004 Apr;20 (4) :393-406.|[2]Mélanie R Tardif, et al. LFA-1 antagonists as agents limiting human immunodeficiency virus type 1 infection and transmission and potentiating the effect of the fusion inhibitor T-20. Antimicrob Agents Chemother. 2009 Nov;53 (11) :4656-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
RR203274L3V 200 µL
Slco4c1 (NM_001002024) Rat Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details MBS9945420-01 48 Well
Horse Serine/Threonine-Protein Kinase D2 (PRKD2) ELISA Kit
Sign In for Pricing
View Details MBS9945420-02 96 Well
Horse Serine/Threonine-Protein Kinase D2 (PRKD2) ELISA Kit
Sign In for Pricing
View Details MBS9945420-03 5x 96 Well
Horse Serine/Threonine-Protein Kinase D2 (PRKD2) ELISA Kit
Sign In for Pricing
View Details MBS9945420-04 10x 96 Well
Horse Serine/Threonine-Protein Kinase D2 (PRKD2) ELISA Kit
Sign In for Pricing
View Details 