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4-Hydroxyphenylbutazone

4-Hydroxyphenylbutazone is a metabolite of Phenylbutazone. Phenylbutazone, a nonsteroidal anti-inflammatory agent (NSAID), is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS) [1].

Product Specifications

CAS Number

16860-43-8

UNSPSC

12352005

Hazard Statement

H301-H319

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/4-hydroxyphenylbutazone.html

Solubility

10 mM in DMSO

Smiles

O=C(C1(CCCC)O)N(C2=CC=CC=C2)N(C3=CC=CC=C3)C1=O

Molecular Formula

C19H20N2O3

Molecular Weight

324.37

Precautions

P264-P270-P280-P305+P351+P338-P330-P405-P501

References & Citations

[1]Hughes MF, et, al. Prostaglandin hydroperoxidase-dependent oxidation of phenylbutazone: relationship to inhibition of prostaglandin cyclooxygenase. Mol Pharmacol. 1988 Aug;34 (2) :186-93.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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