EZH2-IN-4
EZH2-IN-4 is an orally active, potent EZH2 inhibitor with IC50s of 0.923 nM and 2.65 nM against wild type (WT) 5-membered (5-mer) EZH2 and mutant 5-mer EZH2, respectively. EZH2-IN-4 has anti-cancer activity[1].
Product Specifications
CAS Number
2088132-99-2
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ezh2-in-4.html
Solubility
10 mM in DMSO
Smiles
CC1=C([C@@H]([C@@]2([H])CC[C@@](N3CC(C3)OC)([H])CC2)C)SC(CCCN4CC5=C(C=C(NC5=O)C)C)=C1C4=O
Molecular Formula
C29H41N3O3S
Molecular Weight
511.72
References & Citations
[1]Esteban DOMINGUEZ, et al. Inhibitors of ezh2. WO2017035060A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EZH2
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