Simufilam (dihydrochloride)

Simufilam dihydrochloride (PTI-125 dihydrochloride) is an orally active FLNA modulator. Simufilam dihydrochloride restores NMDAR signaling and Arc expression. Simufilam dihydrochloride inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Aβ42-induced neuroinflammation and tau protein hyperphosphorylation. Simufilam dihydrochloride can be used for research of Alzheimer's disease[1][2][3].

Product Specifications

CAS Number

[2480226-06-8]

Product Name Alternative

PTI-125 (dihydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Amyloid-β; iGluR; mTOR; Tau Protein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/simufilam-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl.[H]Cl

Molecular Formula

C15H23Cl2N3O

Molecular Weight

332.27

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Wang HY, et al. Simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer's disease patient lymphocytes. Front Aging. 2023 Jun 29;4:1175601.|[2]Wang HY, et al. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci. 2012 Jul 18;32 (29) :9773-84.|[3]Wang HY, et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017 Jul;55:99-114.