CM121
CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.54 μM; Kd=1.1 μM) with a variety of hydrophobic interactions[1].
Product Specifications
CAS Number
[2204230-40-8]
UNSPSC
12352005
Target
Aldehyde Dehydrogenase (ALDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/cm121.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN(C2=CC=C(C#N)C=C2)N=C1C3=CC=C(S(=O)(C)=O)C=C3)NC4=CC=CC(F)=C4
Molecular Formula
C24H17FN4O3S
Molecular Weight
460.48
References & Citations
[1]Chen Y, et al. Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors. ACS Chem Biol. 2018;13 (3) :582-590
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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