ACAT-IN-10 (dihydrochloride)
ACAT-IN-10 dihydrochloride is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 197. ACAT-IN-10 dihydrochloride weakly inhibits NF-κB mediated transcription[1].
Product Specifications
CAS Number
[199983-77-2]
UNSPSC
12352005
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/acat-in-10-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=S(OC1=C(C(C)C)C=C(NC([C@@H](N)CCCCN)=O)C=C1C(C)C)(NC(CC2=C(C(C)C)C=C(C(C)C)C=C2C(C)C)=O)=O.[H]Cl.[H]Cl
Molecular Formula
C35H58Cl2N4O5S
Molecular Weight
717.83
References & Citations
[1]Joseph Anthony Cornicelli, et al. Sulfonylaminocarbonyl derivatives for the treatment of nuclear factor-kappa B mediated diseases and disorders. EP1236468A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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