ACAT-IN-10 (dihydrochloride)

ACAT-IN-10 dihydrochloride is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 197. ACAT-IN-10 dihydrochloride weakly inhibits NF-κB mediated transcription[1].

Product Specifications

CAS Number

[199983-77-2]

UNSPSC

12352005

Target

Acyltransferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/acat-in-10-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=S(OC1=C(C(C)C)C=C(NC([C@@H](N)CCCCN)=O)C=C1C(C)C)(NC(CC2=C(C(C)C)C=C(C(C)C)C=C2C(C)C)=O)=O.[H]Cl.[H]Cl

Molecular Formula

C35H58Cl2N4O5S

Molecular Weight

717.83

References & Citations

[1]Joseph Anthony Cornicelli, et al. Sulfonylaminocarbonyl derivatives for the treatment of nuclear factor-kappa B mediated diseases and disorders. EP1236468A1.