Epiboxidine (hydrochloride)

Epiboxidine hydrochloride is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine hydrochloride is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418[1].

Product Specifications

CAS Number

[862909-67-9]

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/epiboxidine-hydrochloride.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

CC1=NOC([C@@H]2[C@@H]3N[C@@H](CC3)C2)=C1.[H]Cl

Molecular Formula

C10H15ClN2O

Molecular Weight

214.69

References & Citations

[1]Fitch RW, et al. Homoepiboxidines: further potent agonists for nicotinic receptors. Bioorg Med Chem. 2004;12 (1) :179-190.|[2]Badio B, et al. Synthesis and nicotinic activity of epiboxidine: an isoxazole analogue of epibatidine. Eur J Pharmacol. 1997;321 (2) :189-194.