Epiboxidine
Epiboxidine is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418[1].
Product Specifications
CAS Number
188895-96-7
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/epiboxidine.html
Solubility
10 mM in DMSO
Smiles
CC1=NOC([C@@H]2[C@@H]3N[C@@H](CC3)C2)=C1
Molecular Formula
C10H14N2O
Molecular Weight
178.23
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Fitch RW, et al. Homoepiboxidines: further potent agonists for nicotinic receptors. Bioorg Med Chem. 2004;12 (1) :179-190.|[2]Badio B, et al. Synthesis and nicotinic activity of epiboxidine: an isoxazole analogue of epibatidine. Eur J Pharmacol. 1997;321 (2) :189-194.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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