Epiboxidine

Epiboxidine is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418[1].

Product Specifications

CAS Number

[188895-96-7]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/epiboxidine.html

Solubility

10 mM in DMSO

Smiles

CC1=NOC([C@@H]2[C@@H]3N[C@@H](CC3)C2)=C1

Molecular Formula

C10H14N2O

Molecular Weight

178.23

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Fitch RW, et al. Homoepiboxidines: further potent agonists for nicotinic receptors. Bioorg Med Chem. 2004;12 (1) :179-190.|[2]Badio B, et al. Synthesis and nicotinic activity of epiboxidine: an isoxazole analogue of epibatidine. Eur J Pharmacol. 1997;321 (2) :189-194.